Depression of Weak Allograft Immunity in the Mouse by Neonatal or Adult Exposure to Urethan1
نویسندگان
چکیده
Treatment of adult mice of three strains with mini mally carcinogenic doses of urethan caused an impair ment of cellular immunity as measured by prolongation of allograft survival. This effect was only detectable at the highest dose of urethan tested (150 mg/mouse) and was confined to the weaker strain combinations examined for allograft prolongation. Newborns appeared to be more susceptible to the depressive effect of urethan than did adults. In the BALB/c strain, doses of 120 and 150 mg urethan administered to adults were ineffectual in pro longing allograft survival. However, a dose of 1.0 mg ad ministered to 4-day-old males (but not females) signifi cantly prolonged allograft survival in some individuals when the mice were tested at 3 months of age. These facts are discussed in light of the pronounced carcino genic effect of urethan in young and newborn mice.
منابع مشابه
Depression of weak allograft immunity in the mouse by neonatal or adult exposure to urethan.
Treatment of adult mice of three strains with mini mally carcinogenic doses of urethan caused an impair ment of cellular immunity as measured by prolongation of allograft survival. This effect was only detectable at the highest dose of urethan tested (150 mg/mouse) and was confined to the weaker strain combinations examined for allograft prolongation. Newborns appeared to be more susceptible to...
متن کاملEffect of maternal anastrozole treatment on ovarian follicle development in neonatal mouse: A morphologic study
Introduction: The origin of neonatal oocyte development is unknown. However, estrogen plays an essential role during development of the female reproductive system. Anastrozole is used as both ovulation stimulating and an anticancer drug. The aim of this study was to evaluate the impact of Anastrozole on follicular development and differentiation in mice. Materials and methods: In the present s...
متن کاملP-59: Investigation of Simultaneous Exposure to Noise and Formaldehyde Vapor on Mouse Reproductive Function
Background: Formaldehyde (FA) is a member of aldehyde family with a simplest organic molecule, used in various industries. Since there is simultaneous exposure of formaldehyde and noise for workers in most of the workplaces and that noise can reinforce the harmful effects of some chemical pollutants. This study aimed to investigate the effects of simultaneous formaldehyde and noise exposure on ...
متن کاملComparison of Neonatal and Adult Mice-derived Sertoli Cells in Support of Expansion of Mouse Spermatogonial Stem Cells In vitro
متن کامل
Depression of Homograft Rejection and Graft-versus-Host Reactivity following 7,12-Dimethylbenz(a)anthracene Exposure in the Rat1
An attempt to demonstrate a significant depression of cell-mediated immunity at the beginning of carcinogenesis by chemicals was made in the rat by skin homografts and graft-vmws-host assays. A weak but highly significant prolongation of survival time was observed when F344 skin grafts were performed, across a weak (non-AgB) histoincompatibility, in Lew rats 10 to 13 days after 7,12-dimethylben...
متن کامل